SPAD Detectors in Process Raman Spectroscopy

SPAD CMOS matrices and time-gated Raman as a pathway for eliminating fluorescence background — a review of recent publications and context for process analyzers.
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SPAD CMOS matrices and time-gated Raman as a pathway for eliminating fluorescence background — a review of recent publications and context for process analyzers.

PAT (Process Analytical Technology) originated in pharmaceuticals, but today its largest field of application is specialty chemistry. A guide to the layers of the PAT stack, technique selection, implementation challenges, and the Gekko Photonics offering — Spectrally X1 INLINE, LAB, PORTABLE, and Spectrally OS.

PITTCON, IFPAC, ICORS, SCIX, ACHEMA — an overview of the key Raman and PAT conferences in 2026 from a process engineer's perspective.

Guide to multi-probe architectures in process Raman — when it is worthwhile, what options are available (time-division multiplexing, spatial multiplexing, distributed configuration), and what to consider when designing with multiple measurement points.

The first quarter of 2026 brought an agreement on the EU Pharma Package, joint FDA/EMA guidelines for AI in pharmaceuticals, finalization of Annex 22, and a full year of compliance with the new Annex 1. What this means for PAT/QbD teams in pharmaceuticals and chemistry.

What realistically distinguishes laboratory Raman spectroscopy from process Raman spectroscopy: architecture, measurement accessibility, calibration, integration with DCS, and the financial model. A comparison from the perspective of a Polish manufacturer.

Review of new Raman publications from AGH, UJ/UJ CM, UW, PG and PW: MXene in Small 2026, Bi2Se3 in Photonics 2026, SERS in diabetes diagnostics, trends in ML and miniaturization — and what this implies for process applications.

Continuous monitoring of free phenol and formaldehyde in a PF resin reactor via inline Raman spectroscopy — how it eliminates analytical delay, reduces operator exposure, and enables real-time control of the condensation endpoint.

AI in Raman Chemometrics — What Publications and Conferences of Early 2026 Have Brought: Lean Chemometrics, Transformers, SANet, FAIR. A Review for PAT Engineers.

Inline process analyzers — comparison of types (Raman, NIR, FT-IR, UV-Vis), measurement architectures, technical parameters, and selection criteria for the process.